Owing to the volume of manuscripts we receive, we must insist that all submissions be made via our online submission system.
Using this system, authors can upload manuscript files (text, figures and supplementary information) directly to our office and check on the status of their manuscripts via e-alerts during the review process. In addition, reviewers can access the manuscript (in a highly secure fashion that maintains referee anonymity) over a direct internet link, which speeds the review process. Revisions should be uploaded via the link provided in the editor's decision letter. Please do not submit revisions as new manuscripts.