Depression and anxiety are among the most prevalent psychological difficulties in adults. The aim of this study was to explore the relationship between neurological threshold in sensory profile, depression, and anxiety. Three hundred fifty-four healthy adults in the age group of 20 to 45 years old completed PROMIS® Depression and PROMIS® Anxiety questionnaire and Adolescent/Adult Sensory Profile®. Data were analyzed through Pearson Correlation. The findings showed that there was a significant positive relationship between low neurological threshold and anxiety (r=.381) and depression (r=.295). Furthermore, there was a significant positive relationship between high neurological threshold and anxiety (r=.115). However, the relationship between high neurological threshold and depression was not statistically significant. We can conclude that individuals’ neurological threshold based on sensory profile might be considered as one of the factors relating to anxiety and depression. This study has implications for mental health professionals and it is recommended to study this component more deeply in future studies.