e-ISSN 2231-8542
ISSN 1511-3701

Home / Regular Issue / JTAS Vol. 17 (1) Jan. 2009 / JST-0078-2008


Alkaloids from Piper nigrum and Piper betle

C.M. Lim, G.C.L. Ee, M. Rahmani and C.F.J. Bong

Pertanika Journal of Tropical Agricultural Science, Volume 17, Issue 1, January 2009

Keywords: Piper nigrum, Piper betle, alkaloids, cytotoxicity

Published on:

An investigation, on the roots of Piper nigrum and the aerial parts of Piper betle, has yielded several alkaloids. The dried root sample of Piper nigrum was extracted using various solvents in increasing polarity. The dried aerial part of Piper betle was extracted using the Soxhlet extraction method. The alkaloids isolated were pellitorine(1), (E)-1-[3',4'- (Methylenedioxy)cinnamoyl]piperidine(2), piperine(3), piperolactam D(4), cepharadione A(5), and 2,4-tetradecadienoic acid isobutyl amide(6). These compounds were isolated using chromatographic methods, while the elucidation of the structures was carried out using MS, IR and NMR techniques. The extracts of Piper nigrum and Piper betle were also tested for cytotoxicity activities. This is the first report on (E)-1-[3',4'-(Methylenedioxy)cinnamoyl] piperidine(2) from Piper nigrum as a natural product.

ISSN 1511-3701

e-ISSN 2231-8542

Article ID


Download Full Article PDF

Share this article

Recent Articles