e-ISSN 2231-8542
ISSN 1511-3701

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Chemical Extraction and Separation from the Amoxicillin Plant's Waste-Stream

M. Mohammadi, G.D. Najafpour and A.A. Ghoreyshi

Pertanika Journal of Tropical Agricultural Science, Volume 17, Issue 1, January 2009

Keywords: Amoxicillin, distribution coefficients, extraction, methyl aceto- acetate, phase separation

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In the production of amoxicillin for the activation of amoxicillin molecule, hydrolysis takes place at the final stage. In the hydrolysis, the side branch of the amoxicillin molecule, which is not activated, is debranched, and methyl aceto-acetate is easily separated from the amoxicillin molecule. It is highly desired to recycle methyl aceto-acetate as the chemical compound which is needed for the reformation of Dane salt. The main objective of this project was to carry out the liquid-liquid extraction for the recovery of methyl aceto-acetate from the waste stream. For this purpose, diluted ammonia solution was used as a solvent for the chemical extraction, and methyl aceto-acetate was extracted from the waste stream. The liquid-liquid extraction was carried out, while the pH was adjusted to 9.56 by adding ammonia solution. The extraction was repeated in three consecutive stages to enhance the yield in this process. The samples were taken from each stage of separation for GC analysis. The result obtained from the organic chemical extraction using ammonia in three consecutive stages of extraction with overall removal efficiency of 75%. The extraction process was accompanied with distillation for chemical recovery. Similarly, the undesired remaining organics were successfully extracted from the waste stream by distillation. The yield and partition coefficients of the extraction process were calculated based on the chemical analysis obtained from the GC results.

ISSN 1511-3701

e-ISSN 2231-8542

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