Subsets of motor skills proficiency are evaluated based on bilateral coordination, balance, running speed and agility, upper-limb coordination and strength. This study was designed to determine the correlation of motor skills proficiency subsets among children with Down syndrome. Thirty-three participants (N = 33, 23 boys and 10 girls) aged 4–12 years underwent selected motor skills proficiency subtests of the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition, Short Form. The measurements included synchronised jumping in place on same side, synchronised tapping of feet and fingers on same side, walking forward on a line, standing on one leg on a balance beam with eyes open, one-legged stationary hop, dropping and catching a ball with both hands, dribbling a ball with alternating hands, knee push-ups, and sit-ups. Running speed and agility were found to be moderately correlated with upper-limb coordination (r = 0.36, p < 0.05). There was no significant relationship between gross motor composite of body control (bilateral coordination subtest and balance subtest) and gross motor composite of strength (running speed and agility subtest, and strength subtest). The motor skills proficiency parameters identified in this study will influence the motor development of children with Down syndrome and therefore, a goal-directed conditioning program can be prepared for their motor progression.