e-ISSN 2231-8542
ISSN 1511-3701

Home / Regular Issue / JTAS Vol. 27 (4) Oct. 2019 / JST-1321-2018


Exploring Potential Neuroprotective Properties of Aqueous Centella asiatica Extract in Chronic Stress-induced Rats

Muhamad Zulhusni Abdul Wahab, Muhammad Zaim Zainal Abidin, Fatin Nadzirah Zakaria, Mohamad Aris Mohd Moklas, Zulkhairi Amom, Nina Keterina Hashim and Razif Dasiman

Pertanika Journal of Tropical Agricultural Science, Volume 27, Issue 4, October 2019

Keywords: Centella asiatica, chronic stress, neuroprotectivity

Published on: 21 October 2019

Centella asiatica is one of the traditional herbs consumed by many communities due to its wide range of applications such as treating Parkinsonism, promoting memory enhancement, and preventing oxidative stress. This study was conducted to investigate the neuroprotective potential of aqueous C. asiatica extract (CAE) against neurodegeneration induced by chronic stress. Administration of CAE at three different dosages (200 mg/kg/day, 400 mg/ kg/day and 800 mg/kg/day) was conducted for a period of 21 days along with exposure to chronic stress using restrainer and forced swimming regimes. The administration of CAE significantly improved the thickness of dentate gyrus and reduced the amount of neuronal cell death at dentate gyrus and CA3 (p<0.05). Additionally, administration of CAE significantly alleviated the expression c-fos protein (p<0.05). Thus, this study highlighted the neuroprotective effect of CAE against neurodegeneration from chronic stress exposure.

ISSN 1511-3701

e-ISSN 2231-8542

Article ID


Download Full Article PDF

Share this article

Recent Articles