Numerous studies of polylactide nanocomposites have been conducted. However, the role and importance of processing conditions is the subject of very few papers. In this work, polylactide and a constant amount (2 %w/w) of organoclayCloisite® 30B via melt intercalation technique were produced. It is generally believed that maximum benefits are achieved when organoclay is well dispersed in PLA matrix. It might be anticipated that melt processing conditions would have an important influence on the nanocomposites formed. Experimental design was carried out based on Box-Behnken methods, a response surface methodology (RSM) well suited to the goal of process optimisation. Three levels of processing temperature, rotor speed and mixing time were chosen in this study. The response was Young's modulus. The interaction effects with the most influence on the Young's modulus of these PLA/organoclay nanocomposites are temperature and speed. The maximum Young's modulus was predicted to be 1211 MPa at a temperature, speed, and time of 175°C, 100 rpm, and 7 min, respectively. Understanding the influence of processing conditions on the mechanical properties is needed for improving nanocomposites properties. Mathematical model and optimisations plot were used to illustrate the relationship between the parameters and mechanical properties considered. Results of the data analysis using Minitab software are presented.