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ISSN 1511-3701

Home / Regular Issue / JTAS Vol. 46 (4) Nov. 2023 / JTAS-2721-2023


Effects of Paracetamol on the Development of Zebrafish (Danio rerio)

Ajeng Istyorini Asmoning Dewanti, Tony Prince Kunjirika, Raden Roro Risang Ayu Dewayani Putri, Ascarti Adaninggar, Anita Restu Puji Raharjeng, Bambang Retnoaji, Ardaning Nuriliani, Fajar Sofyantoro, Nur Indah Septriani and Hendry T. S. S. G. Saragih

Pertanika Journal of Tropical Agricultural Science, Volume 46, Issue 4, November 2023


Keywords: Danio rerio, embryo development, paracetamol, pigmentation, zebrafish

Published on: 27 November 2023

The misuse of paracetamol is becoming more prevalent worldwide. Due to non-compliance with recommended dosage and regulations, paracetamol consumption can result in serious health issues such as liver necrosis, kidney damage, heart damage, and hematological changes. This study sought to investigate the impact of paracetamol on the development of zebrafish embryos, which are often used as a model for assessing the effect of drug exposure on animals. The results indicated that paracetamol negatively affects the hatching and survival rates of zebrafish. Additionally, paracetamol exposure caused spinal abnormalities, pericardial edema, hypopigmentation, reduced heart rate, and spontaneous movement in zebrafish larvae. The developmental abnormalities in zebrafish were more significant with higher concentrations and longer exposure times. These findings may provide valuable insights into the detrimental impact of paracetamol on aquatic animals.

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