This paper examines the effect of work-life balance from the perspective of work-to-family conflict (W-FC) and work-to-family enrichment (W-FE) in relation to job satisfaction among academics in Malaysia. A survey method using self-administrated questionnaire was adopted to gather data from 307 respondents. Results were analysed using AMOS 23 and SPSS23. Findings showed that all W-FC and W-FE dimensions were significantly correlated with job satisfaction. However, for direct effect result, only W-FE capital significantly affected job satisfaction whereas none of W-FC dimensions found to have had an effect on job satisfaction. This study contributes to the body of knowledge on work-life balance and job satisfaction among Malaysian Research University academics. The findings provide useful information for university academics and human resource practitioner for future organisational improvement and policy development.