Titanium (Ti) and Ti-based alloys presence the most widely applied as advanced biomaterials in biomedical implant applications. Moreover, these alloys are known to be the most valuable metallic materials including spinal cord surgical treatment. It becomes an interest due to its advantages compared to others, including its bio compatibility and corrosion resistant. However, an issue arises when it comes for permanent implant application as the alloy has a possible toxic effect produced from chemical reaction between body fluid environments with alloys chemical compositions. It also relies on the performance of neighbouring bone tissue to integrate with the implant surface. Abnormalities usually happen when surrounding tissue shows poor responses and rejection of implants that would leads to body inflammation. These cause an increase in foreign body reaction leading to severe body tissue response and thus, loosening of the implant. Corrosion effects and biocompatibility behaviour of implantation usage also become one of the reasons of implant damage. Here, this paper reviews the importance of using Ti and Ti-based alloys in biomedical implantation, especially in orthopaedic spinal cord injury. It also reviews the basic aspects of corrosion effects that lead to implant mechanical damage, poor response of body rejection and biocompatibility behaviour of implantation usage.